{"id":45581,"date":"2023-11-20T05:21:37","date_gmt":"2023-11-20T11:21:37","guid":{"rendered":"https:\/\/stage.cancerimagingarchive.net\/analysis-result\/tcga-kirc-radiogenomics\/"},"modified":"2024-11-07T12:21:53","modified_gmt":"2024-11-07T18:21:53","slug":"tcga-kirc-radiogenomics","status":"publish","type":"tcia_analysis_result","link":"https:\/\/stage.cancerimagingarchive.net\/analysis-result\/tcga-kirc-radiogenomics\/","title":{"rendered":"TCGA-KIRC-RADIOGENOMICS"},"featured_media":0,"template":"","class_list":["post-45581","tcia_analysis_result","type-tcia_analysis_result","status-publish"],"cancer_types":["Renal Clear Cell Carcinoma"],"citations":[45573,45575,9225],"result_doi":"10.7937\/K9\/TCIA.2014.K6M61GDW","result_download_info":"","result_downloads":[45577],"version_change_log_archived":"Version 1 (Current): 2015\/05\/28\r\n   Data TypeDownload all or Query\/FilterImage Data (DICOM)Supplemental Data (CSV)","versions":false,"additional_resources":"","cancer_locations":["Kidney"],"publications_related":"","result_page_accessibility":"Public","detailed_description":"","publications_using":"TCIA maintains\u00a0<a href=\"https:\/\/commons.datacite.org\/doi.org\/10.7937\/K9\/TCIA.2014.K6M61GDW\">a list of publications<\/a>\u00a0that leveraged this dataset. If you have a manuscript you\u2019d like to add please\u00a0<a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\">contact TCIA\u2019s Helpdesk<\/a>.","result_title":"Radiogenomics of Clear Cell Renal Cell Carcinoma: Preliminary Findings of The Cancer Genome Atlas-Renal Cell Carcinoma (TCGA-RCC) Research Group","species":false,"version_number":"1","date_updated":"2015-05-28","related_collections":[44001],"result_short_title":"TCGA-KIRC-Radiogenomics","subjects":"103","related_analysis_results":false,"result_browse_title":"Radiogenomics of Clear Cell Renal Cell Carcinoma: Preliminary Findings of The Cancer Genome Atlas-Renal Cell Carcinoma (TCGA-RCC) Research Group (TCGA-KIRC-Radiogenomics)","supporting_data":["Radiologist assessments of image features"],"version_change_log":"","collections":"Below is a list of the Collections used in these analyses:\r\n<table><colgroup> <col \/> <col \/> <col \/><\/colgroup>\r\n<tbody>\r\n<tr>\r\n<th>Source Data Type<\/th>\r\n<th>Download all or Query\/Filter<\/th>\r\n<th>License<\/th>\r\n<\/tr>\r\n<tr>\r\n<td>Corresponding Original MR Images from TCGA-KIRC (DICOM, 103 subjects, 118 studies, 738 series, 49815 files, 21.11 GB)<\/td>\r\n<td>\r\n<div>\r\n\r\n<a href=\"\/wp-content\/uploads\/doiJNLP-DG2Mvxzc.tcia\" download=\"doiJNLP-DG2Mvxzc.tcia\"><button><i><\/i> Download<\/button><\/a>(Download requires the <a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\">NBIA Data Retriever<\/a>)\r\n\r\n<\/div><\/td>\r\n<td>\r\n<div>\r\n\r\n<a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/\">CC BY 3.0<\/a>\r\n\r\n<\/div><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<ul>\r\n \t<li><a href=\"https:\/\/doi.org\/10.7937\/K9\/TCIA.2016.V6PBVTDR\">TCGA-KIRC<\/a><\/li>\r\n<\/ul>","result_summary":"<h4>PURPOSE:<\/h4>\r\nTo investigate associations between imaging features and mutational status of clear cell renal cell carcinoma (ccRCC).\r\n<h4>MATERIALS AND METHODS:<\/h4>\r\nThis multi-institutional, multi-reader study included 103 patients (77 men; median age 59 years, range 34-79) with ccRCC examined with CT in 81 patients, MRI in 19, and both CT and MRI in three; images were downloaded from The Cancer Imaging Archive, an NCI-funded project for genome-mapping and analyses. Imaging features [size (mm), margin (well-defined or ill-defined), composition (solid or cystic), necrosis (for solid tumors: 0%, 1%-33%, 34%-66% or &gt;66%), growth pattern (endophytic, &lt;50% exophytic, or \u226550% exophytic), and calcification (present, absent, or indeterminate)] were reviewed independently by three readers blinded to mutational data. The association of imaging features with mutational status (VHL, BAP1, PBRM1, SETD2, KDM5C, and MUC4) was assessed.\r\n<h4>RESULTS:<\/h4>\r\nMedian tumor size was 49 mm (range 14-162 mm), 73 (71%) tumors had well-defined margins, 98 (95%) tumors were solid, 95 (92%) showed presence of necrosis, 46 (45%) had \u226550% exophytic component, and 18 (19.8%) had calcification. VHL (n = 52) and PBRM1 (n = 24) were the most common mutations. BAP1 mutation was associated with ill-defined margin and presence of calcification (p = 0.02 and 0.002, respectively, Pearson's x2 test); MUC4 mutation was associated with an exophytic growth pattern (p = 0.002, Mann-Whitney U test).\r\n<h4>CONCLUSIONS:<\/h4>\r\nBAP1 mutation was associated with ill-defined tumor margins and presence of calcification; MUC4 mutation was associated with exophytic growth. Given the known prognostic implications of BAP1 and MUC4 mutations, these results support using radiogenomics to aid in prognostication and management.","collection_downloads":[45579],"result_featured_image":false,"result_acknowledgements":"","hide_from_browse_table":"0","program":["TCGA"],"_links":{"self":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/analysis-results\/45581","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/analysis-results"}],"about":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/types\/tcia_analysis_result"}],"version-history":[{"count":2,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/analysis-results\/45581\/revisions"}],"predecessor-version":[{"id":49799,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/analysis-results\/45581\/revisions\/49799"}],"wp:attachment":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/media?parent=45581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}