{"id":41233,"date":"2023-11-20T00:49:31","date_gmt":"2023-11-20T06:49:31","guid":{"rendered":"https:\/\/stage.cancerimagingarchive.net\/collection\/acrin-flt-breast\/"},"modified":"2024-08-14T14:58:09","modified_gmt":"2024-08-14T19:58:09","slug":"acrin-flt-breast","status":"publish","type":"tcia_collection","link":"https:\/\/stage.cancerimagingarchive.net\/collection\/acrin-flt-breast\/","title":{"rendered":"ACRIN-FLT-BREAST"},"featured_media":6535,"template":"","class_list":["post-41233","tcia_collection","type-tcia_collection","status-publish","has-post-thumbnail"],"cancer_types":["Breast Cancer"],"citations":[41221,41223,9225],"collection_doi":"10.7937\/K9\/TCIA.2017.ol20zmxg","collection_download_info":"","collection_downloads":[41225,41227],"versions":[41231],"additional_resources":"The NCI Cancer Research Data Commons (CRDC) provides access to additional data and a cloud-based data science infrastructure that connects data sets with analytics tools to allow users to share, integrate, analyze, and visualize cancer research data.\r\n<ul>\r\n \t<li><a href=\"https:\/\/portal.imaging.datacommons.cancer.gov\/explore\/filters\/?collection_id=acrin_flt_breast\">Imaging Data Commons (IDC)<\/a> (Imaging Data)<\/li>\r\n<\/ul>\r\nThe following external resources are not hosted or supported by TCIA, but may be useful to researchers utilizing this collection.\r\n<ul>\r\n \t<li><a href=\"https:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/a> entry about the Trial <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT00572728\"> NCT00572728, \"3'-Deoxy-3'-18F Fluorothymidine PET\/CT in Predicting Response To Chemotherapy Before Surgery in Patients With Locally Advanced Breast Cancer\"<\/a><\/li>\r\n<\/ul>","cancer_locations":["Breast"],"collection_page_accessibility":"Public","publications_related":"","version_change_log_archived":"<h3>Version 2 (Current): Updated 2020\/01\/24<\/h3><table><colgroup> <col \/> <col \/> <\/colgroup><tbody><tr><th colspan=\"1\">Data Type<\/th><th colspan=\"1\">Download all or Query\/Filter<\/th><\/tr><tr><td colspan=\"1\">Images (DICOM, 74.2 GB)<\/td><td colspan=\"1\"><div><p>\u00a0 <a href=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-53 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" \/><\/a> <a href=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-52 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" \/><\/a><\/p><p>(Download requires\u00a0<a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\">NBIA Data Retriever<\/a>\u00a0App)<\/p><\/div><\/td><\/tr><tr><td>Clinical (XLS, zip, 192 KB)<\/td><td><div><p><br \/><a href=\"\/wp-content\/uploads\/ACRIN-FLT-Breast-6688-Clinical-Data.zip\" download=\"ACRIN-FLT-Breast-6688-Clinical-Data.zip\"><button><i><\/i> Download<\/button><\/a>\u00a0<\/p><\/div><\/td><\/tr><\/tbody><\/table><h3>Version 1: Updated 2017\/12\/11<\/h3><table><colgroup> <col \/> <col \/> <\/colgroup><tbody><tr><th colspan=\"1\">Data Type<\/th><th colspan=\"1\">Download all or Query\/Filter<\/th><\/tr><tr><td colspan=\"1\">Images (DICOM, 70.8 GB)<\/td><td colspan=\"1\"><div><p>\u00a0 <a href=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-53 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" \/><\/a> <a href=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-282 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" \/><\/a><\/p><p>(Download requires\u00a0<a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\">NBIA Data Retriever<\/a>\u00a0App)<\/p><\/div><\/td><\/tr><\/tbody><\/table>","collection_status":"Complete","publications_using":"TCIA maintains <a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\">a list of publications<\/a> that leverage our data. If you have a publication you'd like to add, please<a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\"> contact TCIA's Helpdesk<\/a>.","related_analysis_results":[46301],"species":["Human"],"version_number":"2","collection_title":"ACRIN 6688","date_updated":"2020-01-24","related_collection":false,"subjects":"83","analysis_results":"","collection_short_title":"ACRIN-FLT-Breast","data_types":["PT","CT","OT"],"version_change_log":"","collection_browse_title":"ACRIN-FLT-Breast (ACRIN 6688)","detailed_description":"<strong>Participant Eligibility and Enrollment<\/strong>:\r\n\r\nCriteria for inclusion were patients with pathologically confirmed breast cancer and determined to be a candidate for primary systemic (neoadjuvant) therapy and for whom surgical resection of residual primary tumor following completion of neoadjuvant therapy is planned. The study was open to enrollment from September 2009 to September 2012. Final accrual to the study was 90 patients, of which 51 were used for the primary aim analysis as reported by <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4737647\/\">Kostakaglu et al. 2015<\/a>.\r\n\r\n<strong>Date Offsets:<\/strong>\r\n\r\nAll dates, like the visit date, are protected by presenting just the year; however, dates are also listed as offset days from the base date. The offset dates are used as a means of protecting patient information provided by the local sites in the original data, while allowing users to determine intervals between events.\u00a0The standard\u00a0DICOM date tags (i.e. birth dates, imaging study dates, etc.) have been de-identified so\u00a0that all patients have a baseline study date of\u00a0January 1, 1960.\u00a0 This falsified date represents the day patients\u00a0were entered into trial database. The number of days between a subject\u2019s longitudinal imaging studies are accurately preserved.\u00a0 A\u00a0patient with a study\u00a0performed on January 4, 1960 means the images were collected\u00a03 days after the base date.\u00a0 For convenience, this calculation has been performed for all scans with the results\u00a0inserted\u00a0in DICOM tag (0012,0050)\u00a0 <em>Clinical Trial Time Point ID<\/em> .\u00a0 This means an imaging study that took place on January 4, 1960 would contain a value of \"3\" in tag (0012,0050).\r\n\r\n<strong>ACRIN 6688 Imaging Protocol:<\/strong>\r\n\r\nTo understand the image series in the ACRIN 6688 image archive, the protocol needs some explanation.\u00a0 The trial, which originated at VCU, required both FDG and FLT imaging on separate days.\u00a0 The protocols were different for each tracer and are described below.\r\n\r\n<u>FDG protocol:<\/u>\u00a0 Following injection of FDG, a one hour uptake period occurred prior to whole body (WB) multiple field-of-view (FOV) imaging.\u00a0 This imaging session will have three series consisting of a CT and two emission images for FDG (an attenuation-corrected image or PET AC, and a non-attenuation corrected image series or PET NAC).\r\n\r\nThe protocol also had dual time point FDG imaging with the second acquisition at two hours after injection, but acquired just 1 FOV over the primary breast lesion.\u00a0 There are a similar three series (CT, PET AC, PET NAC), and may appear as a separate study.\r\n\r\nPeriodically, sites uploaded images of FDG studies close in time to the FLT imaging time points, which were also added to the archive. These studies, which were not required by the ACRIN 6688 protocol, were all standard clinical whole body imaging at 1 hour after FDG injection and are comprised of three series (CT, PET AC, PET NAC).\r\n\r\n<u>FLT Protocol:<\/u>\u00a0 ACRIN 6688 began by requiring dynamic FLT imaging followed by WB scanning.\u00a0 Concurrent with injection, a 45 frame dynamic imaging sequence was acquired over 1 FOV for one hour.\u00a0 The sites were also required to provide a summed 30-60-minute image series from the dynamic study.\u00a0 The WB scan occurred within 10 minutes of the completion of the dynamic study.\u00a0 Thus, there are six series associated with this imaging session, namely three single FOV series (PET AC dynamic, the CT, the summed 30-60 min PET AC) and three WB series (CT, PET AC and PET NAC).\r\n\r\nTo encourage patient recruitment to the trial, the requirement of dynamic imaging was relaxed after about 20 patients had been enrolled.\u00a0 However, the protocol still required WB FLT imaging at one hour after injection to fulfill the primary aims of the study. <strong>\u00a0<\/strong>\r\n\r\n<strong>Overview of Clinical Data<\/strong>:\r\n\r\nCase numbers from the clinical data files correlate directly with the case numbers from the image archive for each ACRIN clinical trial.\r\n\r\nThe basic data flow for legacy ACRIN multi-center clinical trials was that all clinical information provided by the local imaging sites were contained in a series of forms.\u00a0 The form data submitted by local investigators to ACRIN during and after the trial, were manually encoded into the ACRIN CTMS (Clinical Trial Management System), and were cross-checked for accuracy by ECOG-ACRIN personnel. These forms, filled out by the local sites, deliver information on imaging, clinical management of the patient and pathology\/outcome variables, like dates of progression and survival, along with other critical information.\u00a0 The image data was initially anonymized while uploading from the local sites through TRIAD software and archived in a DICOM database at ACRIN.\r\n\r\nAfter the trial accrual had ended, the clinical data was sent to the Brown statistical center, that is funded by NCI to provide support for ECOG-ACRIN clinical trials, specifically for analysis of the primary and sometimes secondary aims of the trial. The statisticians at Brown strip all the actual dates, names and other PHI from the CTMS data and create a <strong>.csv file for each form<\/strong> that has selected information useful for analysis of the trial data.\u00a0 A <strong>Form Description<\/strong> file detailing all the forms used in the study accompanies the .csv data files.\u00a0 Additionally, the accompanying <strong>Data Dictionary<\/strong> file lists each element for each form that has been selected for data retention along with a description of each form element.\r\n\r\n<strong>Extracting clinical (non-imaging) data example: <\/strong>\r\n\r\nBeginning with the <strong>Form Description<\/strong> file, select the form with the desired information needed, such as form BA.csv the patient baseline medical history. Next, using the <strong>Data Dictionary<\/strong> file, select the tab corresponding to the form of interest (eg., BA). The Excel file lists the form number, variable name, its description or label, the type of data, and, when applicable, the option codes and corresponding text values (option code:description pairs like 1=\u2019No\u2019, 2=\u2019Yes\u2019; or 1=\u2019Baseline\u2019, 2=\u2019Post treatment\u2019) for each data element available from the form. \u00a0In the example in Figure 2, the BA form element 7 reports the number of live births for the patient.\u00a0 In the corresponding BA.csf file column G lists the number of live births for each patient, identified by case number (cn) in column A.\r\n<p align=\"center\"><a href=\"\/wp-content\/uploads\/image2018-8-14_14-55-49.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-54 size-medium\" src=\"\/wp-content\/uploads\/image2018-8-14_14-55-49.png\" \/><\/a><\/p>\r\nFigure 2: In this example of extracting clinical data, the first step is to 1) find the form from the form list, 2Find the desired element and description in the Data Dictionary and finally 3) extract the values from the .csv data file.\r\n\r\nACRIN 6688 has about 40 forms, each appears as a separate tab in the Excel Data Dictionary file. For trials, other than ACRIN 6688, the form element descriptions of the <strong>Data Dictionary<\/strong> are in one spreadsheet.\r\n\r\nThe procedure above is basically how the statisticians organized the selected data for export, but the structure of the data dictionaries and individual forms are different for each clinical trial.\u00a0ACRIN 6688 has about 40 forms, with several thousand form elements.","supporting_data":["Clinical"],"collection_featured_image":{"ID":"6535","post_author":"29","post_date":"2023-09-13 08:46:18","post_date_gmt":"2023-09-13 13:46:18","post_content":"","post_title":"image2018-8-14_14-27-5","post_excerpt":"","post_status":"inherit","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"image2018-8-14_14-27-5","to_ping":"","pinged":"","post_modified":"2023-11-20 00:49:31","post_modified_gmt":"2023-11-20 06:49:31","post_content_filtered":"","post_parent":"41233","guid":"https:\/\/stage.cancerimagingarchive.net\/wp-content\/uploads\/image2018-8-14_14-27-5.png","menu_order":"0","post_type":"attachment","post_mime_type":"image\/png","comment_count":"0","pod_item_id":"6535"},"collection_summary":"<p>The objective of the ACRIN 6688 multi-center clinical trial was to correlate changes measured by <sup>18<\/sup>F-FLT PET imaging, a measure of cellular proliferation, in the primary tumor early during NAC (neo-adjuvant chemotherapy) with pCR (pathologic complete response) in locally advanced breast cancer patients. The trial also examined both pre-therapy and post-therapy association of <sup>18<\/sup>F-FLT uptake with the tissue proliferative marker Ki-67 to compare <sup>18<\/sup>F-FLT PET\/CT against an accepted reference standard for cellular proliferation. The trial protocol is graphically described in the figure below. Additional information about the trial is available in the <a href=\"\/wp-content\/uploads\/ACRIN-6688_protocol.pdf\" download=\"ACRIN-6688_protocol.pdf\" data-linked-resource-container-id=\"30671268\" data-linked-resource-container-version=\"54\" data-linked-resource-content-type=\"application\/pdf\" data-linked-resource-default-alias=\"ACRIN 6688_protocol.pdf\" data-linked-resource-id=\"145753915\" data-linked-resource-type=\"attachment\" data-linked-resource-version=\"1\" data-nice-type=\"PDF Document\"> Study Protocol <\/a>and <a href=\"\/wp-content\/uploads\/ACRIN-6688_CRF-Set.pdf\" download=\"ACRIN-6688_CRF-Set.pdf\" data-linked-resource-container-id=\"30671268\" data-linked-resource-container-version=\"54\" data-linked-resource-content-type=\"application\/pdf\" data-linked-resource-default-alias=\"ACRIN 6688_CRF Set.pdf\" data-linked-resource-id=\"145753917\" data-linked-resource-type=\"attachment\" data-linked-resource-version=\"1\" data-nice-type=\"PDF Document\">Case Report Forms<\/a>.\u00a0<\/p><p>Potentially three <sup>18<\/sup> FLT\/CT imaging sessions would be conducted at the times indicated above for the 90 enrolled patients on the study. However, only 43 patients completed all three scans, 54 patients had pre\/post therapy scans of which 51 were evaluable for the primary aim (see <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4737647\/\">Kostakaglu et al. 2015<\/a> ).<\/p>","collection_acknowledgements":"<p>This shared data set was provided by Paul R. Jolles, MD, and David Mankoff, MD, PhD, and Lale Kostakoglu, MD, MPH, in collaboration with the American College of Radiology Core Lab. Many thanks are due to the ACRIN 6688 trial team, and all the patients participating in the study.\u00a0This study was supported by American College of Radiology Imaging network (ACRIN), which received funding from the National Cancer Institute through\u00a0UO1 CA080098, U01\u00a0CA190254\u00a0and\u00a0R50\u00a0CA211270 (Muzi), under the American Recovery and Reinvestment ACT of 2009 (ARRA) and UO1 CA079778.\u00a0<\/p><p>Please see <a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/Public\/QIN+ECOG-ACRIN+Data+Sharing\">QIN ECOG-ACRIN Data Sharing<\/a> page for an overview and list of other ECOG-ACRIN data collections available on TCIA.<\/p>","collection_funding":"","hide_from_browse_table":"0","program":["NCI Trials"],"_links":{"self":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/41233","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections"}],"about":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/types\/tcia_collection"}],"version-history":[{"count":1,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/41233\/revisions"}],"predecessor-version":[{"id":47275,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/41233\/revisions\/47275"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/media\/6535"}],"wp:attachment":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/media?parent=41233"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}