{"id":42565,"date":"2023-11-20T02:37:27","date_gmt":"2023-11-20T08:37:27","guid":{"rendered":"https:\/\/stage.cancerimagingarchive.net\/collection\/pdmr-bl0293-f563\/"},"modified":"2024-04-30T19:49:50","modified_gmt":"2024-05-01T00:49:50","slug":"pdmr-bl0293-f563","status":"publish","type":"tcia_collection","link":"https:\/\/stage.cancerimagingarchive.net\/collection\/pdmr-bl0293-f563\/","title":{"rendered":"PDMR-BL0293-F563"},"featured_media":0,"template":"","class_list":["post-42565","tcia_collection","type-tcia_collection","status-publish"],"cancer_types":["Bladder Cancer"],"citations":[42559,42561,9225],"collection_doi":"10.7937\/tcia.2019.b6u7wmqw","collection_download_info":"","collection_downloads":[42563,48599],"versions":false,"additional_resources":"The National Cancer Institute (NCI) has developed a national repository of Patient-Derived Models (PDMs) comprised of patient-derived xenografts (PDXs), in vitro patient-derived tumor cell cultures (PDCs) and cancer associated fibroblasts (CAFs) as well as patient-derived organoids (PDOrg). These models serve as a resource for public-private partnerships and for academic drug discovery efforts. These PDMs are clinically-annotated with molecular information and made available in the <a href=\"https:\/\/pdmr.cancer.gov\/default.htm\">Patient-Derived Model Repository<\/a>. Data related to the specific subjects in this Collection can be found at:\r\n<ul>\r\n \t<li><a href=\"https:\/\/pdmdb.cancer.gov\/pls\/apex\/f?p=101:4:14488639586634::NO:4:P4_SPECIMENSEQNBR:8\">PDMR-BL0293-F563<\/a><\/li>\r\n<\/ul>\r\nThe NCI Cancer Research Data Commons (CRDC) provides access to additional data and a cloud-based data science infrastructure that connects data sets with analytics tools to allow users to share, integrate, analyze, and visualize cancer research data.\r\n<ul>\r\n \t<li><a href=\"https:\/\/portal.imaging.datacommons.cancer.gov\/explore\/filters\/?collection_id=pdmr_bl0293_f563\">Imaging Data Commons (IDC)<\/a>\u00a0(Imaging Data)<\/li>\r\n<\/ul>","cancer_locations":["Bladder"],"collection_page_accessibility":"Public","publications_related":"","version_change_log_archived":"<h3>Version 1 (Current): Updated 2019\/08\/28<\/h3><table><colgroup><col \/><col \/><\/colgroup><tbody><tr><th>Data Type<\/th><th>Download all or Query\/Filter<\/th><\/tr><tr><td>Images (DICOM, 3.2 GB)<\/td><td><div><p><a href=\"\/wp-content\/uploads\/PDMR-BL0293-F563-manifest-08282019.tcia\" download=\"PDMR-BL0293-F563-manifest-08282019.tcia\"><button><i><\/i> Download<\/button><\/a>\u00a0 <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/?MinNumberOfStudiesCriteria=1&amp;CollectionCriteria=PDMR-BL0293-F563\"><button><i><\/i> Search<\/button><\/a>\u00a0<\/p><p>(Download requires\u00a0the\u00a0<a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\">NBIA Data Retriever<\/a>)<\/p><\/div><\/td><\/tr><\/tbody><\/table>","collection_status":"Complete","publications_using":"TCIA maintains <a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\">a list of publications<\/a> which leverage TCIA data. If you have a manuscript you'd like to add please <a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\">contact TCIA's Helpdesk<\/a>.","related_analysis_results":false,"species":["Mouse"],"version_number":"1","collection_title":"Imaging characterization of a metastatic patient derived model of bladder cancer: BL0293F","date_updated":"2019-08-28","related_collection":false,"subjects":"19","analysis_results":"","collection_short_title":"PDMR-BL0293-F563","data_types":["MR"],"version_change_log":"","collection_browse_title":"PDMR-BL0293-F563","detailed_description":"This <a href=\"\/wp-content\/uploads\/SOP50101_MRI-T2-Weighted-Non-Contrast-Protocol_Single-Mouse-Pulmonary-Gated-and-Multi-Mouse-Non-Gated.pdf\" download=\"SOP50101_MRI-T2-Weighted-Non-Contrast-Protocol_Single-Mouse-Pulmonary-Gated-and-Multi-Mouse-Non-Gated.pdf\" data-linked-resource-container-id=\"52757379\" data-linked-resource-container-version=\"25\" data-linked-resource-content-type=\"application\/pdf\" data-linked-resource-default-alias=\"SOP50101_MRI T2 Weighted Non-Contrast Protocol_Single Mouse Pulmonary Gated and Multi-Mouse Non-Gated.pdf\" data-linked-resource-id=\"61079921\" data-linked-resource-type=\"attachment\" data-linked-resource-version=\"1\" data-nice-type=\"PDF Document\">Standard Operating Procedure (SOP)<\/a> describes the procedures for animal handling and\u00a0monitoring, anesthesia, daily MRI QC\/QA, and MRI sequences for single and multi-mouse imaging for detection and monitoring of tumors and metastatic lesions. This SOP is used\/performed by the Small Animal Imaging Program (SAIP) at NCI-Frederick, Frederick National Laboratory for Cancer Research.\r\n\r\n--\r\n\r\nIn addition to images, this collection may include Raw Data Storage SOP Class instances with <strong>MR Modality<\/strong>, generated by a Philips MR scanner; this data is not useful to anyone without the proprietary software to interpret it.","supporting_data":["Clinical"],"collection_featured_image":false,"collection_summary":"<p>Pre-clinical animal models of spontaneous metastatic cancer are infrequent; the few that exist\u00a0are resource intensive because determination of the presence of metastatic disease,\u00a0metastatic burden, and response to therapy normally require animal sacrifice and extensive\u00a0pathological examination. We recently identified and characterized a patient derived xenograft\u00a0model with metastatic potential, bladder xenograft BL0293-F563, developed by Jackson\u00a0Laboratories and the University of California at Davis. In this study we performed a detailed\u00a0imaging characterization of this model, which develops spontaneous liver and bone\u00a0metastases. Using non-contrast T2 weighted MRI, hepatic metastases were demonstrated in\u00a0over 70% of animals at 52 days post tumor implantation without resection of the xenograft and\u00a0in 100% of animals at day 52 following resection of the xenograft. T2w turbo spin echo (T2wTSE) sequence was applied in the coronal view with a repetition time (TR) 5333ms, echo time\u00a0(TE) 65ms, with an in-plane pixel of 0.180 \u00d7 0.180 mm2. A Spectral Presaturation with\u00a0Inversion Recovery (SPIR) sequence (Philips Healthcare, Best, The Netherlands) was used to\u00a0suppress the fat component and assist in distinguishing fat from cystic mass and tumor\u00a0tissue. In a group of animals receiving one cycle of effective chemotherapy ([Temozolomide;\u00a0(50 mg\/kg; PO, QDx5)] plus [(veliparib, a poly (ADP-ribose) polymerase inhibitor) (7.75 mg\/kg;\u00a0PO; BIDx7)]), no animals demonstrated metastasis by imaging. The imaging characteristics of\u00a0this model, which is available from the National Cancer Institute Patient-Derived Models\u00a0Repository (<a href=\"https:\/\/pdmr.cancer.gov\/\">https:\/\/pdmr.cancer.gov\/<\/a>), is highly favorable for preclinical research studies of\u00a0metastatic disease when used in conjunction with non-contrast T2 weighted MRI.<\/p>","collection_acknowledgements":"<ul><li><p>We would like to thank Nimit Patel of the Small Animal Imaging Program for analyzing ultrasound and assisting with the experiment; Simone Difilippantonio for coordinating her staff and Amy James of the Animal Research Technical Support Program for preparing the drug and administration, measuring body weights, and tumor excision, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research.<\/p><\/li><li><p>This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract Number HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.<\/p><\/li><\/ul>","collection_funding":"","hide_from_browse_table":"0","program":["PDMR"],"_links":{"self":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/42565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections"}],"about":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/types\/tcia_collection"}],"version-history":[{"count":1,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/42565\/revisions"}],"predecessor-version":[{"id":47571,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/42565\/revisions\/47571"}],"wp:attachment":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/media?parent=42565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}