{"id":43903,"date":"2023-11-20T03:57:53","date_gmt":"2023-11-20T09:57:53","guid":{"rendered":"https:\/\/stage.cancerimagingarchive.net\/collection\/tcga-gbm\/"},"modified":"2024-08-23T18:54:43","modified_gmt":"2024-08-23T23:54:43","slug":"tcga-gbm","status":"publish","type":"tcia_collection","link":"https:\/\/stage.cancerimagingarchive.net\/collection\/tcga-gbm\/","title":{"rendered":"TCGA-GBM"},"featured_media":0,"template":"","class_list":["post-43903","tcia_collection","type-tcia_collection","status-publish"],"cancer_types":["Glioblastoma Multiforme"],"citations":[43861,43733,9225],"collection_doi":"10.7937\/K9\/TCIA.2016.RNYFUYE9","collection_download_info":"Some data in this collection contains images that could potentially be used to reconstruct a human face. To safeguard the privacy of participants, users must sign and submit a <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/4556915\/TCIA%20Restricted%20License%2020220519.pdf?version=1&amp;modificationDate=1652964581655&amp;api=v2\">TCIA Restricted License Agreement<\/a> to <a href=\"mailto:help@cancerimagingarchive.net\">help@cancerimagingarchive.net<\/a> before accessing the data.","collection_downloads":[43865],"versions":[43895,43897,43899,43901],"additional_resources":"The NCI Cancer Research Data Commons (CRDC) provides access to additional data and a cloud-based data science infrastructure that connects data sets with analytics tools to allow users to share, integrate, analyze, and visualize cancer research data.\r\n<ul>\r\n \t<li><a href=\"https:\/\/portal.imaging.datacommons.cancer.gov\/explore\/filters\/?collection_id=tcga_gbm\">Imaging Data Commons (IDC)<\/a>\u00a0(Imaging Data)<\/li>\r\n \t<li><a href=\"https:\/\/portal.gdc.cancer.gov\/projects\/TCGA-GBM\">Genomic Data Commons (GDC)<\/a>\u00a0(Genomic, Digitized Histopathology &amp; Clinical Data)\r\n<ul>\r\n \t<li><a href=\"https:\/\/portal.gdc.cancer.gov\/image-viewer?filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22content%22%3A%7B%22field%22%3A%22cases.case_id%22%2C%22value%22%3A%5B%22set_id%3AYEEmK4gB-Ny-1EyOwW07%22%5D%7D%2C%22op%22%3A%22IN%22%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.project_id%22%2C%22value%22%3A%5B%22TCGA-GBM%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22files.data_type%22%2C%22value%22%3A%5B%22Slide%20Image%22%5D%7D%7D%5D%7D\">Digitized Histopathology<\/a><\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ul>","cancer_locations":["Brain"],"collection_page_accessibility":"Limited","publications_related":"","version_change_log_archived":"<h3>Version 5\u00a0(Current): Updated 2023\/08\/07<\/h3><p>Repaired a DICOM tag(0008,0005) to value \"ISO_IR 100\"\u00a0 in 5 series of ID TCGA-08-0380.\u00a0<\/p><h3>Version 4: Updated 2020\/05\/29<\/h3><table><colgroup> <col \/> <col \/> <\/colgroup><tbody><tr><th colspan=\"1\">Data Type<\/th><th colspan=\"1\">Download all or Query\/Filter<\/th><\/tr><tr><td>Images (DICOM, 73.5GB)<\/td><td><div><p><br \/><a href=\"\/wp-content\/uploads\/TCIA_TCGA-GBM_09-16-2015.tcia\" download=\"TCIA_TCGA-GBM_09-16-2015.tcia\"><button><i><\/i> Download<\/button><\/a>\u00a0 <a href=\"https:\/\/www.cancerimagingarchive.net\/nbia-search\/?CollectionCriteria=TCGA-GBM\"><button><i><\/i> Search<\/button><\/a>\u00a0 (Download requires the\u00a0<a href=\"\/display\/NBIA\/Downloading+TCIA+Images\">NBIA Data Retriever<\/a>)<\/p><\/div><\/td><\/tr><tr><td>Tissue Slide Images (web)<\/td><td><div><p><br \/><a href=\"https:\/\/portal.gdc.cancer.gov\/image-viewer?filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22content%22%3A%7B%22field%22%3A%22cases.case_id%22%2C%22value%22%3A%5B%22set_id%3AYEEmK4gB-Ny-1EyOwW07%22%5D%7D%2C%22op%22%3A%22IN%22%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.project_id%22%2C%22value%22%3A%5B%22TCGA-GBM%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22files.data_type%22%2C%22value%22%3A%5B%22Slide%20Image%22%5D%7D%7D%5D%7D\"><button><i><\/i> Search<\/button><\/a>\u00a0<\/p><\/div><\/td><\/tr><tr><td>Clinical Data (TXT)<\/td><td><div><p><br \/><a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/1966258\/gdc_download_clinical_gbm.tar.gz?api=v2\" download=\"\"><button><i><\/i> Download<\/button><\/a>\u00a0<\/p><\/div><\/td><\/tr><tr><td>Biomedical Data (TXT)<\/td><td><div><p><br \/><a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/1966258\/gdc_download_biomedical_gbm.tar.gz?api=v2\" download=\"\"><button><i><\/i> Download<\/button><\/a>\u00a0<\/p><\/div><\/td><\/tr><tr><td>Genomics (web)<\/td><td><div><p><a href=\"https:\/\/portal.gdc.cancer.gov\/projects\/TCGA-GBM\"><button><i><\/i> Search<\/button><\/a>\u00a0<\/p><\/div><\/td><\/tr><\/tbody><\/table><p>Updated clinical data link with latest spreadsheets from GDC. Added new biomedical spreadsheets from GDC.<\/p><h3>Version 3: Updated 2015\/09\/16<\/h3><table><colgroup> <col \/> <col \/> <\/colgroup><tbody><tr><th>Data Type<\/th><th>Download all or Query\/Filter<\/th><\/tr><tr><td>Images (DICOM, 73.5GB)<\/td><td><div><p><a href=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-281 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" \/><\/a> <a href=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-282 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" \/><\/a><\/p><p>(Download requires the\u00a0<a href=\"\/display\/NBIA\/Downloading+TCIA+Images\">NBIA Data Retriever<\/a>)<\/p><\/div><\/td><\/tr><tr><td>Clinical Data (TXT)<\/td><td><div><a href=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-281 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" \/><\/a><\/div><\/td><\/tr><tr><td>Genomics (web)<\/td><td><div><a href=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-282 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" \/><\/a><\/div><\/td><\/tr><\/tbody><\/table><p>\u00a01 new subject added.<\/p><h3>Version 2: Updated 2016\/01\/05<\/h3><table><colgroup> <col \/> <col \/> <\/colgroup><tbody><tr><th>Data Type<\/th><th>Download all or Query\/Filter<\/th><\/tr><tr><td>Images (DICOM, 72.8GB)<\/td><td><div><p><a href=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-281 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" \/><\/a><\/p><p>(Download requires the\u00a0<a href=\"\/display\/NBIA\/Downloading+TCIA+Images\">NBIA Data Retriever<\/a>)<\/p><\/div><\/td><\/tr><tr><td>Clinical Data (TXT)<\/td><td><div><a href=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-281 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" \/><\/a><\/div><\/td><\/tr><tr><td>Genomics (web)<\/td><td><div><a href=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-282 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" \/><\/a><\/div><\/td><\/tr><\/tbody><\/table><p>Extracted latest release of clinical data (TXT) from the GDC Data Portal.<\/p><h3>Version 1: Updated 2014\/12\/30<\/h3><table><colgroup> <col \/> <col \/> <\/colgroup><tbody><tr><th colspan=\"1\">Data Type<\/th><th colspan=\"1\">Download all or Query\/Filter<\/th><\/tr><tr><td>Images (DICOM, 72.8GB)<\/td><td><div><p><a href=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-281 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" \/><\/a><\/p><p>(Download requires the\u00a0<a href=\"\/display\/NBIA\/Downloading+TCIA+Images\">NBIA Data Retriever<\/a>)<\/p><\/div><\/td><\/tr><tr><td colspan=\"1\">Clinical Data (TXT)<\/td><td colspan=\"1\"><div><a href=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-281 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_download_button.png\" \/><\/a><\/div><\/td><\/tr><tr><td colspan=\"1\">Genomics (web)<\/td><td colspan=\"1\"><div><a href=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css alignright wp-image-282 size-medium\" src=\"\/wp-content\/uploads\/tcia_wiki_search_button.png\" \/><\/a><\/div><\/td><\/tr><\/tbody><\/table><p>On 03-01-2013 available subjects in TCIA were reduced from 279 to 240 because some cases were subsequently excluded from the GDC Data Portal.<\/p>","collection_status":"Complete","publications_using":"TCIA maintains\u00a0<a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\">a list of publications<\/a>\u00a0which leverage our data. If you have a publication you'd like to add please <a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\">contact TCIA's Helpdesk<\/a>.","related_analysis_results":[45543,45571,45601,45609,45683,45713,45725,45847,45965,46121,46609],"species":["Human"],"version_number":"5","collection_title":"The Cancer Genome Atlas Glioblastoma Multiforme Collection","date_updated":"2023-08-07","related_collection":false,"subjects":"262","analysis_results":"","collection_short_title":"TCGA-GBM","data_types":["MR","CT","DX"],"version_change_log":"Repaired a DICOM tag(0008,0005) to value \"ISO_IR 100\"\u00a0 in 5 series of ID <span style=\"color: #212529;\">TCGA-08-0380<\/span>.","collection_browse_title":"TCGA-GBM","detailed_description":"<h3>GDC Data Portal - Clinical and Genomic Data<\/h3>\r\nThe <a href=\"https:\/\/portal.gdc.cancer.gov\/exploration?filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.program.name%22%2C%22value%22%3A%5B%22TCGA%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.project_id%22%2C%22value%22%3A%5B%22TCGA-GBM%22%5D%7D%7D%5D%7D\">GDC Data Portal<\/a> has extensive clinical and genomic data, which can be matched to the patient identifiers of the images here in TCIA. Below is a snapshot of clinical data extracted on 1\/5\/2016:\r\n<ul>\r\n \t<li><a href=\"\/wp-content\/uploads\/TCGA-GBM-Clinical-Data-1516.zip\" download=\"TCGA-GBM-Clinical-Data-1516.zip\" data-linked-resource-container-id=\"1966258\" data-linked-resource-container-version=\"140\" data-linked-resource-content-type=\"application\/zip\" data-linked-resource-default-alias=\"TCGA-GBM Clinical Data 1516.zip\" data-linked-resource-id=\"22643022\" data-linked-resource-type=\"attachment\" data-linked-resource-version=\"1\" data-nice-type=\"Zip Archive\">TCGA-GBM Clinical Data.zip<\/a>\u00a0 (<strong> NOTE:<\/strong>\u00a0this is just a representative sample of what's available. Visit the <a href=\"https:\/\/portal.gdc.cancer.gov\/exploration?facetTab=clinical&amp;filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.project_id%22%2C%22value%22%3A%5B%22TCGA-GBM%22%5D%7D%7D%5D%7D\">GDC Data Portal<\/a> to obtain the latest\/complete data set)<\/li>\r\n<\/ul>\r\nExplanations of the clinical data can be found on the Biospecimen Core Resource Clinical Data Forms linked below:\r\n<ul>\r\n \t<li><a href=\"https:\/\/www.nationwidechildrens.org\/-\/media\/nch\/research\/documents\/tcga\/gbm-case-quality-control-form.ashx\">GBM Case Quality Control Form<\/a><\/li>\r\n \t<li><a href=\"https:\/\/www.nationwidechildrens.org\/-\/media\/nch\/research\/documents\/tcga\/gbm-enrollment-form.ashx\">GBM Enrollment Form<\/a><\/li>\r\n \t<li><a href=\"https:\/\/www.nationwidechildrens.org\/-\/media\/nch\/research\/documents\/tcga\/gbm-followup-form.ashx\">GBM Follow-Up Form<\/a><\/li>\r\n<\/ul>\r\n<h3>A Note about TCIA and TCGA Subject Identifiers and Dates<\/h3>\r\n<strong>Subject Identifiers:<\/strong>\u00a0a subject with radiology images stored in TCIA is identified with a Patient ID that is identical to the Patient ID of the same subject with demographic, clinical, pathological, and\/or genomic data stored in TCGA. For each TCGA case, the baseline TCGA imaging studies found on TCIA are pre-surgical.\r\n\r\n<strong>Dates:<\/strong>\u00a0TCIA and TCGA handle dates differently, and there are no immediate plans to reconcile:\r\n<ul>\r\n \t<li><u>TCIA Dates:<\/u>\u00a0dates (be they birth dates, imaging study dates, etc.) in the Digital Imaging and Communications in Medicine (DICOM) headers of TCIA radiology images have been offset by a random number of days. The offset is a number of days between 3 and 10 years prior to the real date that is consistent for each TCIA image-submitting site and collection, but that varies among sites and among collections from the same site. Thus, the number of days between a subject\u2019s longitudinal imaging studies are accurately preserved when more than one study has been archived while still meeting HIPAA requirements.<\/li>\r\n \t<li><u>TCGA Dates:<\/u>\u00a0the patient demographic and clinical event dates are all the number of days from the index date, which is the actual date of pathologic diagnosis. So all the dates in the data are relative negative or positive integers, except for the \u201cdays_to_pathologic_diagnosis\u201d value, which is 0 \u2013 the index date. The years of birth and diagnosis are maintained in the distributed clinical data file. The NCI retains a copy of the data with complete dates, but those data are not made available.With regard to other TCGA dates, if a date comes from a HIPAA \u201ccovered entity\u2019s\u201d medical record, it is turned into the relative day count from the index date. Dates like the date TCGA received the specimen or when the TCGA case report form was filled out are not such covered dates, and they will appear as\u00a0real dates (month, day, and year).<\/li>\r\n<\/ul>","supporting_data":["Clinical","Genomics","Image Analyses","Histopathology"],"collection_featured_image":false,"collection_summary":"<p>The Cancer Genome Atlas Glioblastoma Multiforme (TCGA-GBM) data collection is part of a larger effort to\u00a0build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from\u00a0<a href=\"http:\/\/cancergenome.nih.gov\/\">The Cancer Genome Atlas (TCGA)<\/a>. Clinical, genetic, and pathological data resides in the\u00a0<a href=\"https:\/\/portal.gdc.cancer.gov\/exploration?filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.program.name%22%2C%22value%22%3A%5B%22TCGA%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.project_id%22%2C%22value%22%3A%5B%22TCGA-GBM%22%5D%7D%7D%5D%7D\">Genomic Data Commons (GDC) Data Portal<\/a> while the radiological data is stored on The Cancer Imaging Archive (TCIA).\u00a0<\/p><p>Matched TCGA patient identifiers allow researchers to explore the TCGA\/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. \u00a0Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. \u00a0For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. \u00a0In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial.\u00a0<\/p><h3>CIP TCGA Radiology Initiative<\/h3><p>Imaging Source Site (ISS) Groups are being populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type\u00a0per\u00a0the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. \u00a0Learn more about the\u00a0<a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/Public\/TCGA+Glioma+Phenotype+Research+Group\">TCGA Glioma Phenotype Research Group<\/a>.<\/p>","collection_acknowledgements":"<p>We would like to acknowledge the individuals and institutions that have provided data for this collection:<\/p><ul><li>Henry Ford Hospital, Detroit, MI - Special thanks to\u00a0<strong>Lisa Scarpace<\/strong>\u00a0and\u00a0<strong>Tom Mikkelsen, MD<\/strong>\u00a0from the Department of Neurosurgery, Hermelin Brain Tumor Center.<\/li><li>University of California, San Francisco, CA - Special thanks to\u00a0<strong>Soonmee Cha, MD<\/strong>\u00a0from the Department of Neurological Surgery, Brain Tumor Research Center.<\/li><li>MD Anderson Cancer Center, Houston, TX - Special thanks to\u00a0<strong>Sujaya Rao<\/strong>\u00a0and\u00a0<strong>Sangeeta Tekchandani<\/strong>\u00a0from the Office of Translational\/Clinical Research.<\/li><li>Emory University, Atlanta, GA - Special thanks to\u00a0<strong>David Gutman, MD, Ph.D.<\/strong>\u00a0and\u00a0<strong>Joel Saltz, MD, Ph.D.<\/strong>\u00a0from the Center for Comprehensive Informatics.<\/li><li>Thomas Jefferson University, Philadelpha, PA \u00a0- Special thanks to\u00a0<strong>Nancy Pedano<\/strong>\u00a0and\u00a0<strong>Adam E. Flanders, MD<\/strong>\u00a0from the Department of Radiology, Jefferson Medical College.<\/li><li>CWRU School of Medicine, Cleveland, OH - Special thanks to\u00a0<strong>Jill Barnholtz-Sloan, Ph.D.<\/strong>\u00a0and\u00a0<strong>Quinn Ostrom, MA, MPH<\/strong>\u00a0from Case Comprehensive Cancer Center.<\/li><li>Duke University School of Medicine, Durham, NC -\u00a0Special thanks to\u00a0<strong>Daniel Barboriak, MD<\/strong>\u00a0and Laura J Pierce.<\/li><li>Fondazione IRCCS Instituto Neuroligico C. Besta, Milan, Italy - Special thanks to <strong>Domenico Aquino<\/strong> and <strong>Alessandro Perin MD<\/strong>.<\/li><\/ul>","collection_funding":"","hide_from_browse_table":"0","program":["TCGA"],"_links":{"self":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/43903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections"}],"about":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/types\/tcia_collection"}],"version-history":[{"count":1,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/43903\/revisions"}],"predecessor-version":[{"id":47399,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/43903\/revisions\/47399"}],"wp:attachment":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/media?parent=43903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}