{"id":49063,"date":"2024-08-30T11:01:15","date_gmt":"2024-08-30T16:01:15","guid":{"rendered":"https:\/\/www.cancerimagingarchive.net\/?post_type=tcia_collection&#038;p=49063"},"modified":"2025-01-14T15:03:50","modified_gmt":"2025-01-14T21:03:50","slug":"cmb-brca","status":"publish","type":"tcia_collection","link":"https:\/\/stage.cancerimagingarchive.net\/collection\/cmb-brca\/","title":{"rendered":"CMB-BRCA"},"featured_media":0,"template":"","class_list":["post-49063","tcia_collection","type-tcia_collection","status-publish"],"cancer_types":["Breast Invasive Carcinoma"],"citations":[49071,49349],"collection_doi":"10.7937\/dx22-8j71","collection_download_info":"","collection_downloads":[50133,49489],"versions":[50105],"additional_resources":"The database of Genotypes and Phenotypes (dbGaP) hosts genomic, phenotypic, and clinical data for NCI's Cancer Moonshot Biobank (CMB) project. Information and access to the data can be found at:\r\n<ul>\r\n \t<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/projects\/gap\/cgi-bin\/study.cgi?study_id=phs002192.v1.p1\">dbGaP - Cancer Moonshot Biobank<\/a> (Genomic, Phenotypic &amp; complete Clinical Data - controlled access)<\/li>\r\n \t<li><a href=\"https:\/\/clinical.datacommons.cancer.gov\/?cid=eb_govdel#\/study\/NCT04314401\">CTDC - Cancer Moonshot Biobank<\/a> (subset of Clinical Data - open access)<\/li>\r\n<\/ul>\r\nThe NCI Cancer Research Data Commons (CRDC) provides access to additional data and a cloud-based data science infrastructure that connects data sets with analytics tools to allow users to share, integrate, analyze, and visualize cancer research data.\r\n<ul>\r\n \t<li><a href=\"https:\/\/portal.imaging.datacommons.cancer.gov\/explore\/filters\/?collection_id=cmb_aml\">Imaging Data Commons (IDC)<\/a>\u00a0(Imaging Data)<\/li>\r\n<\/ul>","cancer_locations":["Breast"],"collection_page_accessibility":"Public","publications_related":"","version_change_log_archived":"","collection_status":"Ongoing","publications_using":"TCIA maintains\u00a0<a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\">a list of publications<\/a> which leverage TCIA data. If you have a manuscript you'd like to add please <a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\">contact TCIA's Helpdesk<\/a>.","related_analysis_results":false,"species":["Human"],"version_number":"2","collection_title":"Cancer Moonshot Biobank - Invasive Breast Carcinoma Cancer Collection","date_updated":"2024-12-17","related_collection":false,"subjects":"26","analysis_results":"","collection_short_title":"CMB-BRCA","data_types":["Histopathology"],"version_change_log":"Radiology imaging added for 1 patient who previously only had pathology imaging.","collection_browse_title":"CMB-BRCA","detailed_description":"<h3>Introduction<\/h3>\r\nBiobank radiology imaging data on TCIA contains the \u201cdays from enrollment (registration)\u201d for each scan, embedded in the DICOM files (DICOM tag (0012,0053)). \u00a0 This allows for temporal alignment between the imaging on TCIA and clinical events data found on the Biobank Catalog.\r\nNote: \u00a0In order that the images display properly in DICOM readers, the radiology imaging data also contains de-identified dates that preserve the temporal sequence relationship between scans in a given study.\r\n<h3>Days from enrollment (registration)<\/h3>\r\nIn addition to modifying the actual date fields in the DICOM header, the \"days from registration\" values are calculated and stored in the DICOM tag<strong>\u00a0(0012,0052)\u00a0Longitudinal Temporal Offset from Event<\/strong>\u00a0with the associated tag\u00a0<strong>(0012,0053) Longitudinal Temporal Event Type<\/strong>\u00a0set to \u201cREGISTRATION\u201d.\u00a0 \u00a0Here is an example DICOM header from a scan where the patient's imaging was performed 2 days before the registration, resulting in a negative offset value.\r\n<div>\r\n<table>\r\n<tbody>\r\n<tr>\r\n<td>(0012,0052)<\/td>\r\n<td>Longitudinal Temporal Offset from Event<\/td>\r\n<td>-2.0<\/td>\r\n<\/tr>\r\n<tr>\r\n<td>(0012,0053)<\/td>\r\n<td>Longitudinal Temporal Event Type<\/td>\r\n<td>REGISTRATION<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\nIf you would like to filter your search results using this information, you can leverage the \"Clinical Trial Time Points\" filter\u00a0 via our data portal at <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/\">https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/<\/a>.\r\n\r\n<a href=\"\/wp-content\/uploads\/image2022-8-23_11-46-31.png\" rel=\"prettyPhoto noopener\"><img class=\"cm-inline-img-css wp-image-302 size-medium alignleft\" src=\"\/wp-content\/uploads\/image2022-8-23_11-46-31.png\" \/><\/a>\r\n\r\n&nbsp;\r\n\r\n&nbsp;\r\n\r\n&nbsp;\r\n\r\n&nbsp;\r\n\r\n&nbsp;\r\n\r\n&nbsp;\r\n\r\n&nbsp;\r\n<h3>De-identification of DICOM dates<\/h3>\r\nDe-identification of dates for this dataset uses the DICOM Part 3.15 Annex E standard \u201cRetain Longitudinal With Modified Dates Option\u201d which allows dates to be retained as long as they are modified from the original date.\u00a0 TCIA implements this using a technique which de-identifies the dates while preserving the longitudinal relationship between them. \u00a0Original dates will be first normalized to January 1, 1960 and then offset relative to the date of registration for each patient.\u00a0 This normalized date system was chosen in order to make it obvious that the dates are not real, and to make it easy to quickly determine how much time has passed between the date of registration and the patients' related imaging studies.\r\n\r\nFor example, if the real date of a patient's registration was 03\/27\/2018 and the original imaging Study Date was 03\/29\/2018 then the anonymized TCIA Study Date would become 01\/03\/1960 (two days after the base date of 1\/1\/1960).","supporting_data":["Clinical"],"collection_featured_image":{"ID":"6787","post_author":"29","post_date":"2023-09-13 09:24:29","post_date_gmt":"2023-09-13 14:24:29","post_content":"","post_title":"NIH-Cancer-Moonshot-logo","post_excerpt":"","post_status":"inherit","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nih-cancer-moonshot-logo","to_ping":"","pinged":"","post_modified":"2023-11-20 01:42:48","post_modified_gmt":"2023-11-20 07:42:48","post_content_filtered":"","post_parent":"41649","guid":"https:\/\/stage.cancerimagingarchive.net\/wp-content\/uploads\/NIH-Cancer-Moonshot-logo.png","menu_order":"0","post_type":"attachment","post_mime_type":"image\/png","comment_count":"0","pod_item_id":"6787"},"collection_summary":"<p>The <a href=\"https:\/\/moonshotbiobank.cancer.gov\/\">Cancer Moonshot Biobank<\/a> is a National Cancer Institute initiative to support current and future investigations into drug resistance and sensitivity and other NCI-sponsored cancer research initiatives, with an aim of improving researchers' understanding of cancer and how to intervene in cancer initiation and progression. During the course of this study, biospecimens (blood and tissue removed during medical procedures) and associated data will be collected longitudinally from at least 1000 patients across at least 10 cancer types, who represent the demographic diversity of the U.S. and receiving <a href=\"https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/standard-of-care\">standard of care cancer treatment<\/a> at multiple <a href=\"https:\/\/ncorp.cancer.gov\/\">NCI Community Oncology Research Program (NCORP)<\/a> sites.<\/p><p>This collection contains de-identified radiology and histopathology imaging procured from subjects in NCI\u2019s Cancer Moonshot Biobank - Invasive Breast Carcinoma Cancer (CMB-BRCA) cohort. Associated genomic, phenotypic and clinical data will be hosted by <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/gap\/\">The Database of Genotypes and Phenotypes (dbGaP)<\/a> and other NCI databases. \u00a0A summary of Cancer Moonshot Biobank imaging efforts can be found on the\u00a0<u><a href=\"https:\/\/www.cancerimagingarchive.net\/research\/cmb\/\">Cancer Moonshot Biobank Imaging<\/a><\/u>\u00a0page.<\/p>","collection_acknowledgements":"","collection_funding":"","hide_from_browse_table":"0","program":["CMB"],"_links":{"self":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/49063","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections"}],"about":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/types\/tcia_collection"}],"version-history":[{"count":1,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/49063\/revisions"}],"predecessor-version":[{"id":49067,"href":"https:\/\/stage.cancerimagingarchive.net\/api\/v1\/collections\/49063\/revisions\/49067"}],"wp:attachment":[{"href":"https:\/\/stage.cancerimagingarchive.net\/api\/wp\/v2\/media?parent=49063"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}