The objective of the ACRIN 6688 multi-center clinical trial was to correlate changes measured by 18F-FLT PET imaging, a measure of cellular proliferation, in the primary tumor early during NAC (neo-adjuvant chemotherapy) with pCR (pathologic complete response) in locally advanced breast cancer patients. The trial also examined both pre-therapy and post-therapy association of 18F-FLT uptake with...
ACRIN-HNSCC-FDG-PET/CT (ACRIN 6685) is a Multicenter Trial of FDG-PET/CT Staging of Head and Neck Cancer and its Impact on the N0 Neck Surgical Treatment in Head and Neck Cancer Patients. The objective of this study was to determine the negative predictive value (NPV) of positron emission tomography (PET)/computed tomography CT for clinically N0 neck based upon pathologic sampling of the neck lymph nodes and to determine...
The objective of the ACRIN 6684 multi-center clinical trial was to determine the association of baseline FMISO PET uptake (maximal tumor to blood ratio, hypoxic volume) and MRI parameters (Ktrans, CBV) with overall survival, time to disease progression, and 6-month progression free survival in participants with newly diagnosed glioblastoma multiforme (GBM). The trial also collected standard brain...
RTOG 0625/ACRIN 6677 is a multicenter, randomized, phase II trial of bevacizumab with irinotecan or temozolomide in recurrent glioblastoma (GBM). This study investigated whether early posttreatment progression on FLAIR or postcontrast MRI assessed by central reading predicts overall survival (OS).
Of 123 enrolled patients, 107 had baseline and at least 1 posttreatment MRI. Two central neuroradiologists...
This dataset relates to NCI Clinical trial, "Magnetic Resonance Imaging in Women Recently Diagnosed With Unilateral Breast Cancer (ACRIN-6667)". The dataset consists of 984 patients but only 969 were included in the primary data analysis due to study criteria.
Even after careful clinical and mammographic evaluation, cancer is found in the contralateral...
This dataset includes abdominal or pelvic enhanced CT images within 10 days before surgery of 230 patients with stage II colorectal cancer (CRC). The inclusion criteria were as follows: (i) patients with radical surgery for CRC (complete removal of the original tumor and regional lymphadenectomy); (ii) patients with stage II CRC confirmed by histology and pathology; (iii) abdominal or pelvic enhanced CT examination...
This collection contains data from the Eastern Cooperative Oncology Group (ECOG) Clinical Trial NCT02933489, “Abbreviated Breast MRI and Digital Tomosynthesis Mammography in Screening Women With Dense Breasts". Principal Investigator: Christopher Comstock. It was sponsored by NCI and performed by the Eastern Cooperative Oncology Group under study...
This data set was provided in association with a challenge competition and related conference session conducted at the AAPM 2019 Annual Meeting.
MRI is popular in radiation oncology because of its...
This collection provides public access to a 3D pathology dataset of prostate cancer, allowing researchers to further investigate various 3D tissue structures and their correlation with prostate cancer patient outcomes (biochemical recurrence). These 3D tissue structures are revealed through: (1) a H&E-analog stain, (2) synthetically generated immunofluorescence staining of CK8 (targeting the luminal epithelial...
This dataset comprises four prevalent AML subtypes with defining genetic abnormalities and typical morphological features according to the WHO 2022 classification: (i) APL with PML::RARA fusion, (ii) AML with NPM1 mutation, (iii) AML with CBFB::MYH11 fusion (without NPM1 mutation), and (iv) AML with RUNX1::RUNX1T1 fusion, as well as a control group of healthy stem cell donors.
A total of 189 peripheral blood...
