TCGA-Breast-Radiogenomics | TCGA Breast Phenotype Research Group Data sets
DOI: 10.7937/K9/TCIA.2014.8SIPIY6G | Data Citation Required | 4.6k Views | 6 Citations | Analysis Result
| Location | Subjects | Size | Updated | |||
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| Breast | Breast | 84 | multi-gene assays | 2018/09/04 |
At the time of our study, 108 cases with breast MRI data were available in the The Cancer Genome Atlas Breast Invasive Carcinoma Collection (TCGA-BRCA) collection. In order to minimize variations in image quality across the multi-institutional cases we included only breast MRI studies acquired on GE 1.5 Tesla magnet strength scanners (GE Medical Systems, Milwaukee, Wisconsin, USA) scanners, yielding a total of 93 cases. We then excluded cases that had missing images in the dynamic sequence (1 patient), or at the time did not have gene expression analysis available in the TCGA Data Portal (8 patients). After these criteria, a dataset of 84 breast cancer patients resulted, with MRIs from four institutions: Memorial Sloan Kettering Cancer Center, the Mayo Clinic, the University of Pittsburgh Medical Center, and the Roswell Park Cancer Institute. The resulting cases contributed by each institution were 9 (date range 1999-2002), 5 (1999-2003), 46 (1999-2004), and 24 (1999-2002), respectively. The dataset of biopsy proven invasive breast cancers included 74 (88%) ductal, 8 (10%) lobular, and 2 (2%) mixed. Of these, 73 (87%) were ER+, 67 (80%) were PR+, and 19 (23%) were HER2+. Various types of analyses were conducted using the combined imaging, genomic, and clinical data. Those analyses are described within several manuscripts created by the group (cited below). Additional information about the methodology for how the Radiologist Annotations file can be found on the TCGA Breast Image Feature Scoring Project page.
Data Access
Version 1: Updated 2018/09/04
| Title | Data Type | Format | Access Points | Subjects | License | Metadata | |||
|---|---|---|---|---|---|---|---|---|---|
| Radiologist Annotations | Radiomic Feature | XLS | CC BY 3.0 | — | |||||
| Segmented Lesions (*.les) | Segmentation | ZIP | 91 | CC BY 3.0 | — | ||||
| Quantitative Radiomic Features | Radiomic Feature | XLS | CC BY 3.0 | — | |||||
| MammaPrint, Oncotype DX, and PAM50 Multi-gene Assays | Classification | XLS | 100 | CC BY 3.0 | — | ||||
| Clinical Data | Demographic, Diagnosis, Follow-Up, Molecular Test, Treatment | XLS | 334 | CC BY 3.0 | — |
Collections Used In This Analysis Result
| Title | Data Type | Format | Access Points | Subjects | License | Metadata | |||
|---|---|---|---|---|---|---|---|---|---|
| Corresponding Original Images from TCGA-BRCA | MR, MG | DICOM | Requires NBIA Data Retriever |
91 | 104 | 1,129 | 114,323 | CC BY 3.0 | View |
Citations & Data Usage Policy
Data Citation Required: Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution must include the following citation, including the Digital Object Identifier:
Data Citation |
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Morris, E., Burnside, E., Whitman, G., Zuley, M., Bonaccio, E., Ganott, M., Sutton, E., Net, J., Brandt, K., Li, H., Drukker, K., Perou, C., & Giger, M. L. (2014). Using Computer-extracted Image Phenotypes from Tumors on Breast MRI to Predict Stage [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/K9/TCIA.2014.8SIPIY6G |
Related Publications
Publications by the Dataset Authors
The authors recommended the following as the best source of additional information about this dataset:
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Guo, W., Li, H., Zhu, Y., Lan, L., Yang, S., Drukker, K., Morris, E., Burnside, E., Whitman, G., Giger, M. L., Ji, Y., & TCGA Breast Phenotype Research Group. (2015). Prediction of clinical phenotypes in invasive breast carcinomas from the integration of radiomics and genomics data. Journal of Medical Imaging, 2(4), 041007. https://doi.org/10.1117/1.jmi.2.4.041007 |
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Burnside E, Drukker K, Li H, Bonaccio E, Zuley M, Ganott M, Net JM, Sutton E, Brandt K, Whitman G, Conzen S, Lan L, Ji Y, Zhu Y, Jaffe C, Huang E, Freymann J, Kirby J, Morris EA, Giger ML. (2016) Using computer-extracted image phenotypes from tumors on breast MRI to predict breast cancer pathologic stage. Cancer 122(5): 748-757 . DOI: 10.1002/cncr.29791 |
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Zhu Y, Li H, Guo W, Drukker K, Lan L, Giger ML*, Ji Y*: Deciphering genomic underpinnings of quantitative MRI-based radiomic phenotypes of invasive breast carcinoma. Nature – Scientific Reports 5:17787. doi: 10.1038/srep17787, 2015. |
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Li H, Zhu Y, Burnside ES, Drukker K, Hoadley KA, Fan C, Conzen SD, Whitman GJ, Sutton EJ, Net JM, Ganott M, Huang E, Morris EA, Perou CM, Ji Y, Giger ML. (2016) MR Imaging radiomics signatures for predicting the risk of breast cancer recurrence as given by research versions of gene assays of MammaPrint, Oncotype DX, and PAM50. Radiology 281(2):382-391. doi: 10.1148/radiol.2016152110 |
Publication Citation |
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Li H, Zhu Y, Burnside ES, …. Perou CM, Ji Y, Giger ML: Quantitative MRI radiomics in the prediction of molecular classifications of breast cancer subtypes in the TCGA/TCIA Dataset. npj Breast Cancer (2016) 2, 16012; doi:10.1038/npjbcancer.2016.12; published online 11 May 2016. |
Research Community Publications
TCIA maintains a list of publications that leveraged this dataset. If you have a manuscript you’d like to add please contact TCIA’s Helpdesk.