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CPTAC-LSCC - The Cancer Imaging Archive (TCIA)
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CPTAC-LSCC


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The Cancer Imaging Archive

CPTAC-LSCC | The Clinical Proteomic Tumor Analysis Consortium Lung Squamous Cell Carcinoma Collection

DOI: 10.7937/K9/TCIA.2018.6EMUB5L2 | Data Citation Required | Image Collection

Location Species Subjects Data Types Cancer Types Size Supporting Data Status Updated
Lung Human 212 CT, PT, Histopathology Squamous Cell Carcinoma 444.6GB Clinical, Genomics, Proteomics Public, Ongoing 2024/04/05

Summary

This collection contains subjects from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium Lung Squamous Cell Carcinoma (CPTAC-LSCC) cohort. CPTAC is a national effort to accelerate the understanding of the molecular basis of cancer through the application of large-scale proteome and genome analysis, or proteogenomics. Radiology and pathology images from CPTAC patients are being collected and made publicly available by The Cancer Imaging Archive to enable researchers to investigate cancer phenotypes which may correlate to corresponding proteomic, genomic and clinical data.

Imaging from each cancer type will be contained in its own TCIA Collection, with the collection name "CPTAC-cancertype".  Radiology imaging is collected from standard of care imaging performed on patients immediately before the pathological diagnosis, and from follow-up scans where available.  For this reason the radiology image data sets are heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. Pathology imaging is collected as part of the CPTAC qualification workflow.  

All CPTAC cohorts are released as either a single combined cohort, or split into Discovery and Confirmatory where applicable.  There are two main types of proteomic studies: discovery proteomics and targeted proteomics. The term "discovery proteomics" is in reference to "untargeted" identification and quantification of a maximal number of proteins in a biological or clinical sample. The term “targeted proteomics” refers to quantitative measurements on a defined subset of total proteins in a biological or clinical sample, often following the completion of discovery proteomics studies to confirm interesting targets selected. Commonly used proteomic technologies and platforms are different types of mass spectrometry and protein microarrays depending on the needs, throughput and sample input requirement of an analysis, with further development on nanotechnologies and automation in the pipeline in order to improve the detection of low abundance proteins, increase throughput, and selectively reach a target protein in vivo.  Once the protein targets of interest are identified, high-throughput targeted assays are developed for confirmatory studies: tests to affirm that the initial tests were accurate. A summary of CPTAC imaging efforts can be found on the CPTAC Imaging Proteomics page. 

CPTAC Imaging Special Interest Group

You can join the CPTAC Imaging Special Interest Group to be notified of webinars & data releases, collaborate on common data wrangling tasks and seek out partners to explore research hypotheses!  Artifacts from previous webinars such as slide decks and video recordings can be found on the CPTAC SIG Webinars page.

 

Data Access

Version 15: Updated 2024/04/05

some series were found to contain head data and moved under access restrictions.

Title Data Type Format Access Points Subjects Studies Series Images License
Images CT, PT DICOM
Download requires NBIA Data Retriever
36 43 233 51,000 CC BY 3.0
Images CT DICOM
Download requires NBIA Data Retriever
1 1 5 1,019 TCIA Restricted
Tissue Slide Images Histopathology SVS
Download requires IBM-Aspera-Connect plugin
212 1,081 CC BY 3.0
Analysis Results Using This Collection
Related Datasets
SAROS
No related Collections found
Legend: Analysis Results| Collections

Additional Resources for this Dataset

The NCI Cancer Research Data Commons (CRDC) provides access to additional data and a cloud-based data science infrastructure that connects data sets with analytics tools to allow users to share, integrate, analyze, and visualize cancer research data.

Citations & Data Usage Policy

Data Citation Required: Users must abide by the TCIA Data Usage Policy and Restrictions. Attribution must include the following citation, including the Digital Object Identifier:

Data Citation

National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC). (2018). The Clinical Proteomic Tumor Analysis Consortium Lung Squamous Cell Carcinoma Collection (CPTAC-LSCC) (Version 15) [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/K9/TCIA.2018.6EMUB5L2

Acknowledgement

The CPTAC program requests that publications using data from this program include the following statement: “Data used in this publication were generated by the National Cancer Institute Clinical Proteomic Tumor Analysis Consortium (CPTAC).”

Detailed Description

Accessing CPTAC publication cohorts

All CPTAC cohorts are released as either a single combined cohort, or split into Discovery and Confirmatory where applicable. In the case of CPTAC-LSCC there was a “Discovery Cohort” release.  Images associated with these cases can be downloaded using the following links:

Accessing the Proteomic & Genomic Clinical Data

To access/download the clinical data on the Proteomic Data Commons (PDC) and Genomic Data Commons (GDC), once you have identified the data of your interest, move to the ‘Clinical’ tab on the browse page. Select the checkbox to select a specific row, all rows on the page or all pages and click the export clinical manifest button in CSV or TSV format on the GDC, or TSV or JSON format on the PDC.

A Note about TCIA and CPTAC Subject Identifiers and Dates

Subject Identifiers:

A subject with radiology and pathology images stored in TCIA is identified with a de-identified project Patient ID that is identical to the Patient ID of the same subject with clinical, proteomic, and/or genomic data stored in other CPTAC databases and web sites.

Dates:

The radiology imaging data is in DICOM format. To provide temporal context information aligned with events in the clinical data set for each patient, TCIA has inserted information in DICOM tag (0012,0050) Clinical Trial Time Point ID. This DICOM tag contains the number of days from the date the patient was initially diagnosed pathologically with the disease to the date of the scan. E.g. a scan acquired 3 days before the diagnosis would contain the value -3. A follow up scan acquired 90 days after diagnosis would contain the value 90.

The DICOM date tags (i.e. birth dates, imaging study dates, etc.) are modified per TCIA’s standard process which offsets them by a random number of days. The offset is a number of days between 3 and 10 years prior to the real date that is consistent for each TCIA image-submitting site and collection, but that varies among sites and among collections from the same site. Thus, the number of days between a subject’s longitudinal imaging studies are accurately preserved when more than one study has been archived while still meeting HIPAA requirements.

Acknowledgements

We would like to acknowledge the individuals and institutions that have provided data for this collection:

  • Beaumont Health System, Royal Oak, MI - Special thanks to George D. Wilson, PhD from the Department of Radiation Oncology Research, Barbara Pruetz of the Biobank, Debra Kapczynski, MHSA, CIIP, RT(R)(CT) and Rachel Deyer from the Department of Diagnostic Radiology.
  • Cureline, Inc. team and clinical network, Brisbane, CA - Special thanks to Olga Potapova, PhD, Vladislav Golubkov, PhD, Victoria Fulidou, MD, Alexander Sviridov, Dmitry Belyaev, MD, Oxana Paklina, MD, Dr.Sc., Galiya Setdikova, MD, PhD, and Denis Golbin, MD, PhD
  • St. Joseph's Hospital and Medical Center, Phoenix, AZ - Special thanks to Jennifer Eschbacher, MD from the Department of Neuropathology, Catherine Seiler, PhDRosy Singh and Beth Hermes from the Biobank Core Facility, and Victor Sisneros, RT(R)(CT), CPSA.
  • International Institute for Molecular Oncology, Poznań, Poland - Special thanks to Maciej Wiznerowicz MD, PhD and Jan Lubiński MD PhD; Wojciech Dyszkiewicz MD, PhD., and Łukasz Gąsiorowski MD from Greater Poland Center of Pulmonology and Thoracic Surgery, Poznań, Poland; Bartosz Kubisa MD, PhD., Malgorzata Wojtys MD and PhD., and Tomasz Grodzki MD, PhD of Regional Hospital Complex, Szczecin, Poland
  • BioPartners, CA - Special thanks to Alexander Gasparian, PhD. from the Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Kakhaber Zaalishvili, MD Medical Advisor and Staff Pathologist at BioPartners, LLC, Milla Gorodnia, President of BioPartners, Inc., Victoria Christensen, Global Business Development/Project Coordination Manager, Oksana Havryliuk, MD. Chief of Research department of radiodiagnostics of NCI (Ukraine), Marianna Gredil’, Director of BioPartners, LLC, and Anna Legenka Chief of the Data Department at BioPartners, LLC 
  • Boston Medical Center, Boston, MA - Special thanks to Chris D. Andry M.Phil, PhD from the Department of Pathology and Laboratory Medicine, Margaret Lavoye, Artem Kaliaev, Wilson Chavez, Stephan Anderson, Jorge Soto, and Mitchell Horn from the Department of Radiology, Elizabeth Duffy, MA and Cheryl Spencer, MA of the Biobank.

Related Publications

Publications by the Dataset Authors

The authors recommended this paper as the best source of additional information about this dataset:

No publications by dataset authors were found.

Research Community Publications

TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you’d like to add please contact TCIA’s Helpdesk.

Other Publications Using this Data

TCIA maintains a list of publications which leverage TCIA data. If you have a manuscript you’d like to add please contact TCIA’s Helpdesk.

Previous Versions

Version 13: Updated 2021/01/27

New Genomic and Proteomic data added

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images SVS
Discovery Study
Download requires NBIA Data Retriever

Version 12: Updated 2020/06/25

Added 12 participants’ radiology imaging from two sites.

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images SVS
Proteomics WEB

Version 11: Updated 2020/03/31

Added 1 radiology subject

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images SVS
Proteomics WEB

Version 10: Updated 2020/02/14

Added 6 new pathology subjects and 74 new pathology images.

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images SVS
Proteomics WEB

Version 9: Updated 2020/01/24

Added 51 new pathology patients and 367 new WSIs.

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images SVS
Proteomics WEB

Version 8: Updated 2019/12/19

Added 3 new radiological subjects.

Transferred two subjects radiology imaging (C3N-00738 C3N-02290) to CPTAC-LUAD as a correction.

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images SVS
Proteomics WEB

Version 7: Updated 2019/09/30

Added New Subjects.

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images SVS
Proteomics WEB

Version 6: Updated 2019/06/30

Added Subjects.

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images SVS
Proteomics WEB

Version 5: Updated 2019/03/31

Added new subjects

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images WEB
Proteomics WEB

Version 4: Updated 2018/12/31

Added new subjects.

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images WEB
Proteomics WEB

Version 3: Updated 2018/06/30

Added new subjects.

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images WEB
Proteomics WEB

Version 2: Updated 2018/01/10

Added new subjects.

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images WEB
Proteomics WEB

Version 1: Updated 2018/01/10

Title Data Type Format Access Points Subjects Studies Series Images License
Images DICOM
Download requires NBIA Data Retriever
Tissue Slide Images WEB
Proteomics WEB

Version 14: Updated 2023/02/24

Radiology modality data cleanup to remove extraneous scans.

Title Data Type Format Access Points Subjects Studies Series Images License
Images CT, PT DICOM
Download requires NBIA Data Retriever
36 43 238 52,019 CC BY 3.0
Tissue Slide Images Histopathology SVS
Download requires IBM-Aspera-Connect plugin
212 1,081 CC BY 3.0